HCID 11819612, compound → HCID 10261633, compound

HRID 2081217Notes

Reaction equation

HRID 2081217 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8]([CH2:12][OH:13])=[CH:7]2>O1CCOCC1.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8]([CH:12]=[O:13])=[CH:7]2

Participants

4

Reactant 1

HCID 11819612HCID 11819612, compound

Product 1

HCID 10261633HCID 10261633, compoundYield 89.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

7-Fluoro-1-methyl-1H-indole-2-methanol (2.0 g) was dissolved in 1,4-dioxan (50 ml). Manganese dioxide (2.91 g) was added and the mixture was heated at reflux for 1 h. The mixture was then filtered and the filtrate was evaporated in vacuo to give the title compound (1.77 g) as a solid, m.p. 61°-63°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1 h
  3. filtrationThe mixture was then filtered
  4. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-3541b782523b4765bc599f7ad6dbef4c
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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