Benzoic Acid → HCID 19799272, compound

HRID 2081227Notes

Reaction equation

HRID 2081227 reaction equation
[F:1][C:2]1[C:10]2[N:9]([CH3:11])[C:8]3[CH2:12][CH2:13][N:14]([CH2:17][C:18]4[N:19]=[CH:20][NH:21][C:22]=4[CH3:23])[C:15](=[O:16])[C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:24]([OH:32])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.CCOCC>CO>[C:24]([OH:32])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[F:1][C:2]1[C:10]2[N:9]([CH3:11])[C:8]3[CH2:12][CH2:13][N:14]([CH2:17][C:18]4[N:19]=[CH:20][NH:21][C:22]=4[CH3:23])[C:15](=[O:16])[C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 243Benzoic AcidHCID 3283Diethyl EtherHCID 172999Lurosetron

Product 1

HCID 19799272HCID 19799272, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl) methyl]-1H-pyrido[4,3-b]indol-1-one (170 mg) in methanol (10 ml) was treated with benzoic acid (66 mg). Ether (ca. 20 ml) was added to precipitate a solid which was filtered off to give the title compound (220 mg), m.p. 169°-171°.

Workup

  1. customto precipitate a solid which
  2. filtrationwas filtered off

Sources & evidence

ORD record
ord-743cd91704b74ae6b930be8aecf7f02e
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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