HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Methylhydroxylamine hydrochloride → (1-azabicyclo-[2,2,2]-octan-3-yl)-ethanone O-methyloxime hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 3-Acetyl quinuclidine hydrochloride | HCID 19799459 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-azabicyclo-[2,2,2]-octan-3-yl)-ethanone O-methyloxime hydrochloride | HCID 86744766 | 67.9% |
Reaction Steps
2.3 g of 3-acetyl quinuclidine hydrochloride (Helv. Chim. Acta (1963) 229, 2658) and 1.02 g of O-methylhydroxylamine hydrochloride are heated for 20 minutes to reflux in 30 cm3 of methanol. The solvent is evaporated and the residue is chromatographed on silica (eluant: chloroform-methanol 7-3). After crystallization from ethanol and from ether, 1.8 g of expected product is obtained. M.p.=186°-188° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183893 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-f27633fe5d1b462e8e26b0afaee73b26 |
| Source note | uspto-grants-1993_02 |