反应详情

2.3 g of 3-acetyl quinuclidine hydrochloride (Helv. Chim. Acta (1963) 229, 2658) and 1.02 g of O-methylhydroxylamine hydrochloride are heated for 20 minutes to reflux in 30 cm3 of methanol. The solvent is evaporated and the residue is chromatographed on silica (eluant: chloroform-methanol 7-3). After crystallization from ethanol and from ether, 1.8 g of expected product is obtained. M.p.=186°-188° C.

1. customThe solvent is evaporated
2. customthe residue is chromatographed on silica (eluant: chloroform-methanol 7-3)
3. customAfter crystallization from ethanol