Sodium Hydroxide → 4-(2-Iodophenoxy)-butyric acid methyl ester

HRID 2081315Notes

Reaction equation

HRID 2081315 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[I:15])C.[OH-].[Na+]>CO>[CH3:1][O:3][C:4](=[O:16])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[I:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 150701154-(2-Iodophenoxy)butyric acid ethyl ester

Product 1

HCID 434795434-(2-Iodophenoxy)-butyric acid methyl esterYield 93.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 5A, 1 g of 4-(2-iodophenoxy)-butyric acid ethyl ester in 10 ml of methanol and 10 ml of 1 n sodium hydroxide solution is saponified, worked up, and 900 mg of 4-(2-iodophenoxy)-butyric acid methyl ester with a melting point of 66.5°-67° C. is obtained.

Sources & evidence

ORD record
ord-cd803c16a9024af0bc3cc197f1df89d5
Source dataset
uspto-grants-1993_02
Patent number
US05183925

Reaction notes

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