Isopropanol → HCID 15070130, compound

HRID 2081316Notes

Reaction equation

HRID 2081316 reaction equation
[I:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[CH:15](O)([CH3:17])[CH3:16]>>[CH:15]([O:9][C:8](=[O:10])[CH2:7][CH2:6][CH2:5][O:4][C:3]1[CH:11]=[CH:12][CH:13]=[CH:14][C:2]=1[I:1])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 15070118HCID 15070118, compound

Product 1

HCID 15070130HCID 15070130, compound

Procedure

A solution of 4-(2-iodophenoxy)-butyric acid in 10 ml of isopropanol is mixed with 0.5 g of Amberlyst 15, stirred overnight at room temperature and then refluxed for 2 hours. Then, it is filtered from the Amberlyst 15, the filtrate is concentrated by evaporation, the residue is taken up in diethyl ether, washed with diluted sodium carbonate solution, dried and concentrated by evaporation. 920 mg of 4-(2-iodophenoxy)butyric acid isopropylester is obtained as a colorless oil.

Workup

  1. temperaturerefluxed for 2 hours
  2. filtrationThen, it is filtered from the Amberlyst 15
  3. concentrationthe filtrate is concentrated by evaporation
  4. washwashed with diluted sodium carbonate solution
  5. customdried
  6. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-8b12818ae43643439d04fef84ec97427
Source dataset
uspto-grants-1993_02
Patent number
US05183925

Reaction notes

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