2-Iodophenol → HCID 15070116, compound

HRID 2081322Notes

Reaction equation

HRID 2081322 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:15]([O:17][C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22]Br)[CH3:16]>>[CH2:15]([O:17][C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[I:1])[CH3:16]

Participants

4

Reactant 3

HCID 107842-IodophenolHCID 10796Cesium carbonateHCID 84580Ethyl 5-bromovalerate

Product 1

HCID 15070116HCID 15070116, compoundYield 38.1%

Procedure

Under the conditions of example 2A, 3 g of 2-iodophenol in the presence of 8.9 g of cesium carbonate is reacted with 2.84 g of 5-bromovaleric acid ethyl ester, worked up, and 1.8 g of 5-(2-iodophenoxy)valeric acid ethyl ester with a boiling point of 210° C./0.4 mbar is obtained as a colorless oil.

Sources & evidence

ORD record
ord-1e821db35e68461bbf0d96dd7bd287f2
Source dataset
uspto-grants-1993_02
Patent number
US05183925

Reaction notes

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