Methyl p-toluenesulfonate → HCID 15052249, compound

HRID 2081503Notes

Reaction equation

HRID 2081503 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:7][S:6][CH2:5][N:4]1[CH3:8].[C:9]1([CH3:20])[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>>[C:9]1([CH3:20])[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:16])=[O:17])=[CH:13][CH:14]=1.[CH3:8][N+:4]1([CH3:9])[C@H:3]([CH2:2][OH:1])[CH2:7][S:6][CH2:5]1

Participants

3

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 13419604HCID 13419604, compound

Product 1

HCID 15052249HCID 15052249, compoundYield 171.8%

Procedure

The procedures of Reference Example 10 were repeated using 520 mg of 4(R)-hydroxymethyl-3-methyl-1,3-thiazolidine and 726 mg of methyl p-toluenesulfonate to give 1070 mg of the desired compound as a white crystalline product.

Sources & evidence

ORD record
ord-9e17f68447a84259b977eaf05ba879db
Source dataset
uspto-grants-1993_02
Patent number
US05183811

Reaction notes

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