反应详情

A solution of 2.23 g of 4-methoxycarbonyl-2-phenylthiazolidine in 20 m of acetonitrile was chilled to -15° C. and, after addition of 4.3 g of 35% formalin and 1.0 g of sodium cyanoborohydride, was stirred for 30 minutes. The mixture was made acidic by addition of acetic acid under chilling with ice and, after addition of water, was made alkaline by addition of potassium carbonate. The alkaline solution was extracted with ether, and the etheral extract was dried over anhydrous sodium sulfate. The extract was placed under reduced pressure to distill of the solvent. The residue was purified by silica gel column chromatography (eluent: chloroform) to give 2.37 g of 4-methoxycarbonyl-3-methyl-2-phenylthiazolidine as a colorless oil.

1. temperatureunder chilling with ice
2. extractionThe alkaline solution was extracted with ether
3. extractionthe etheral extract
4. dry with materialwas dried over anhydrous sodium sulfate
5. distillationto distill of the solvent
6. customThe residue was purified by silica gel column chromatography (eluent: chloroform)