Chloroform → HCID 19780040, compound

HRID 2081540Notes

Reaction equation

HRID 2081540 reaction equation
[BH4-].[Na+].[CH2:3]([O:10][C:11]1[C:16]([C:17]#[N:18])=[CH:15][C:14]([C:19](=[O:21])[CH3:20])=[C:13]([CH3:22])[N:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)(Cl)Cl>C(O)C.C(O)(=O)C>[CH2:3]([O:10][C:11]1[C:16]([C:17]#[N:18])=[CH:15][C:14]([CH:19]([OH:21])[CH3:20])=[C:13]([CH3:22])[N:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

6

Reactant 3

HCID 6212ChloroformHCID 4311764Sodium borohydrideHCID 10445614HCID 10445614, compound

Product 1

HCID 19780040HCID 19780040, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 702EthanolSolvent

Procedure

Sodium borohydride (0.35 g, 0.0092 mol) was added at room temperature to 2-benzyloxy-5-acetyl-6-methylpyridin-3-carbonitrile (2.44 g, 0.0092 mol) in ethanol (60 mL). After 2 hours chloroform was added plus a few drops of acetic acid. After washing with water and brine, the chloroform solution was evaporated to give product which was not purified further.

Workup

  1. washAfter washing with water and brine
  2. customthe chloroform solution was evaporated
  3. customto give product which
  4. customwas not purified further

Sources & evidence

ORD record
ord-d281242594964377a93aa98f7623ae69
Source dataset
uspto-grants-1993_02
Patent number
US05185251

Reaction notes

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