Methanesulfonic Acid → HCID 86746537, compound

HRID 2081568Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([CH2:19][C@H:20]([CH3:21])[N:8]3[CH:7]=[C:6]([C:22]([OH:24])=[O:23])[C:5]2=[O:25])[C:11]=1[N:12]1[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]1.[CH3:26][S:27]([OH:30])(=[O:29])=[O:28]>>[CH3:26][S:27]([OH:30])(=[O:29])=[O:28].[F:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([CH2:19][C@H:20]([CH3:21])[N:8]3[CH:7]=[C:6]([C:22]([OH:24])=[O:23])[C:5]2=[O:25])[C:11]=1[N:12]1[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]1

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 10315550(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

Product 1

HCID 86746537HCID 86746537, compound

Procedure

(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid and methanesulfonic acid were used, and treated in a manner analogous to Example 21, to give the title compound.

Workup

additiontreated in a manner analogous to Example 21

Sources & evidence

ORD record: ord-53c5f25db787484e8ca58115c1e6fee3
Source dataset: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05185337

Reaction notes

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