Ammonium Chloride → HCID 19780247, compound

HRID 2081589Notes

Reaction equation

HRID 2081589 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][C:5]1[N:10]=[C:9]([C:11](=[NH:14])OC)[CH:8]=[CH:7][CH:6]=1.[Cl-].[NH4+:20]>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][C:5]1[N:10]=[C:9]([C:11]([NH2:20])=[NH:14])[CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 53896835HCID 53896835, compound

Product 1

HCID 19780247HCID 19780247, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 6-(o-chlorobenzyl)-2-picoline imidate 5.5 g, 0.021 moles) and ammonium chloride (1.28 g, 0.024 moles) in ethanol (40 ml) was refluxed for 4 hours. The ethanol was removed in vacuo to give 6-(o-chlorobenzyl)-2-picoline amidine hydrochloride which was used in the final stage without further purification.

Workup

  1. temperaturewas refluxed for 4 hours
  2. customThe ethanol was removed in vacuo

Sources & evidence

ORD record
ord-5fbed3513ee54e6bbff1079d2aed26cf
Source dataset
uspto-grants-1993_02
Patent number
US05185339

Reaction notes

Loading…