Tetrahydrofuran → N-[4-[[2-(Aminocarbonyl)-4-pyridinyl]oxy]-2,5-difluorophenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

HRID 208180Notes

Reaction equation

HRID 208180 reaction equation
[C:1]([NH2:2])(=[O:3])[c:4]1[n:5][cH:6][cH:7][c:8]([O:10][c:11]2[cH:12][c:13]([F:27])[c:14]([NH:18][C:19](=[O:20])[C:21]3([C:24](=[O:25])[OH:26])[CH2:22][CH2:23]3)[cH:15][c:16]2[F:17])[cH:9]1.[NH2:28][c:29]1[cH:30][cH:31][c:32]([F:33])[cH:34][cH:35]1.[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[C:1]([NH2:2])(=[O:3])[c:4]1[n:5][cH:6][cH:7][c:8]([O:10][c:11]2[cH:12][c:13]([F:27])[c:14]([NH:18][C:19](=[O:20])[C:21]3([C:24](=[O:26])[NH:28][c:29]4[cH:30][cH:31][c:32]([F:33])[cH:34][cH:35]4)[CH2:22][CH2:23]3)[cH:15][c:16]2[F:17])[cH:9]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 97314-FluoroanilineHCID 68690514HCID 68690514, compound

Product 1

HCID 59597002N-[4-[[2-(Aminocarbonyl)-4-pyridinyl]oxy]-2,5-difluorophenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Sources & evidence

ORD record
ord-975f18f608684849951e97af113e7fcc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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