HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (E)-3-[2-n-Butyl-1-{(4-cyanophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(thiophen-2-yl)propanoate | HCID 566367 | — |
| Reactant | 2-n-Butyl-1-(4-carboethoxy-2-chlorobenzyl)imidazole-5-aldehyde | HCID 19936789 | — |
| Reactant | (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid | HCID 86746549 | — |
| Reactant | HCID 178441598 | HCID 178441598 | — |
| Product | (E)-3-[2-n-Butyl-1-{(4-cyanophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid | HCID 14952919 | — |
Reaction Steps
The title compound was prepared using 2-n-butyl-[(4-cyanophenyl)methyl]imidazole-5-aldehyde (prepared by the method of Example 42 describing the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde) and methyl 3-(2-thienyl)propanoate by the procedure of Example 1 (iv, Method B), except, instead of basic hydrolysis of the ester with sodium hydroxide, potassium carbonate hydrolysis was employed; mp 190°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185351 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-3c63297cde3f4721a85a226c69054eec |
| Source note | uspto-grants-1993_02 |