HRID2081865

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID14798

Sodium Hydroxide

HNaO

HCID566367

Methyl 3-(thiophen-2-yl)propanoate

C8H10O2S

结构：CCCCc1ncc(C=O)n1Cc1ccc(C(=O)OCC)cc1Cl

HCID19936789

未命名化合物

结构：CCCCc1ncc(/C(C)=C(/C(=O)O)c2ccncc2)n1Cc1ccccc1Cl

HCID86746549

未命名化合物

HCID178441598

未命名化合物

PRODUCTS

生成物

$结构：CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C#N)cc1$

HCID14952919

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using 2-n-butyl-[(4-cyanophenyl)methyl]imidazole-5-aldehyde (prepared by the method of Example 42 describing the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde) and methyl 3-(2-thienyl)propanoate by the procedure of Example 1 (iv, Method B), except, instead of basic hydrolysis of the ester with sodium hydroxide, potassium carbonate hydrolysis was employed; mp 190°-192° C.

WORKUP

后处理

customprepared by the method of Example 42 describing

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c63297cde3f4721a85a226c69054eec
来源数据集: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05185351
来源说明: uspto-grants-1993_02

反应 SMILES

C(C1[NH:6]C(C=O)=C(CC2C=CC(C#N)=CC=2)N=1)CCC.[CH2:21]([C:25]1[N:26]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39](OCC)=O)=[CH:35][C:34]=2Cl)[C:27]([CH:30]=O)=[CH:28][N:29]=1)[CH2:22][CH2:23][CH3:24].[S:45]1[CH:49]=[CH:48][CH:47]=[C:46]1[CH2:50][CH2:51][C:52]([O:54]C)=[O:53].C(C1N(CC2C=CC=CC=2Cl)C(/C(/C)=C(\C2C=CN=CC=2)/C(O)=O)=CN=1)CCC.[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>>[CH2:21]([C:25]1[N:26]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]#[N:6])=[CH:37][CH:38]=2)[C:27](/[CH:30]=[C:51](\[CH2:50][C:46]2[S:45][CH:49]=[CH:48][CH:47]=2)/[C:52]([OH:54])=[O:53])=[CH:28][N:29]=1)[CH2:22][CH2:23][CH3:24]