HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Thienyl)butanoic acid methyl ester → 4-[[2-butyl-5-[(E)-2-carboxy-4-thiophen-2-ylbut-1-enyl]imidazol-1-yl]methyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Thienyl)butanoic acid methyl ester | HCID 140766 | — |
| Reactant | 1-methyl-1H-imidazole-5-carbaldehyde | HCID 573592 | — |
| Reactant | Methyl 3-(4-pyridyl)propanoate | HCID 3704115 | — |
| Reactant | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | HCID 10047444 | — |
| Reactant | 1H-Imidazole-5-carboxaldehyde, 2-butyl-1-[(2-chlorophenyl)methyl]- | HCID 10107530 | — |
| Product | 4-[[2-butyl-5-[(E)-2-carboxy-4-thiophen-2-ylbut-1-enyl]imidazol-1-yl]methyl]benzoic acid | HCID 14952960 | — |
Reaction Steps
The title compound was prepared following the procedure of Example 20 replacing methyl 3-(4-pyridyl)propanoate with methyl 4-(2-thienyl)butanoate and 2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde with 2-n-butyl-1-)4-carbomethoxyphenyl)methyl-1H-imidazol-5-carboxaldehyde; mp 244°-246° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185351 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-be4cd52926ba466fbc598ef1afc1077c |
| Source note | uspto-grants-1993_02 |