HCID 14858794, compound → HCID 14858793, compound

HRID 2081951Notes

Reaction equation

HRID 2081951 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])[OH:10])=[CH:4][CH:3]=1>CO.[Pd]>[C:5]1([CH2:8][N:1]([CH2:9][C:11]2[CH:12]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:2]2[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[C:13]([OH:15])=[O:14])[OH:10])=[CH:6][CH:7]=2)[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=1

Participants

4

Reactant 1

HCID 14858794HCID 14858794, compound

Product 1

HCID 14858793HCID 14858793, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Compound VII (32 mg), obtained in Example 10, was dissolved in methanol (2 ml). Pd/C (10 mg) was added and the reaction mixture flushed with hydrogen and stirred for about 1.5 hours until all spotting material was gone, as determined by TLC in CH2Cl2 :ethylacetate (1:1), yielding 16.2 mg (86 percent yield) of Compound 5b.

Workup

  1. customthe reaction mixture flushed with hydrogen

Sources & evidence

ORD record
ord-2e4ffcfa218d421a9b022bb2bdb1eed0
Source dataset
uspto-grants-1993_02
Patent number
US05187086

Reaction notes

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