4-Fluoroaniline → Benzyl 4-(((4-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate

HRID 208202Notes

Reaction equation

HRID 208202 reaction equation
[Cl+3:27]([O-:28])([O-:29])([O-:30])[O-:31].[Li+:32].[NH2:19][c:20]1[cH:21][cH:22][c:23]([F:24])[cH:25][cH:26]1.[O:1]1[CH2:2][C:3]12[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH2:7][CH2:8]2>>[OH:1][C:3]1([CH2:2][NH:19][c:20]2[cH:21][cH:22][c:23]([F:24])[cH:25][cH:26]2)[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 97314-FluoroanilineHCID 28486Lithium ionHCID 123351PerchlorateHCID 13016598Benzyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylate

Product 1

HCID 56773849Benzyl 4-(((4-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-b8e97526ceaf45dbabb51f77c32445bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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