Hydrochloric Acid → HCID 131717749, compound

Participants

Reaction Steps

Bis(trifluoroacetic acid salts) of 7β-amino-3-[3-formamido-2-(3-formyloxypropyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate (5.30 g) was added to methanol (31.8 ml). Concentrated hydrochloric acid was added dropwise thereto with stirring at room temperature. The mixture was stirred for 3 hours. The reaction mixture was pulverized with ethyl acetate (400 ml) to give 7β-amino-3-[3-amino-2-(3-hydroxypropyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate trihydrochloride.

Provenance & Evidence