Hydrochloric Acid → HCID 131717749, compound

HRID 2082026Notes

Reaction equation

HRID 2082026 reaction equation
[NH2:1][C@@H:2]1[C:27](=[O:28])[N:4]2[C:5]([C:24]([O-:26])=[O:25])=[C:6]([CH2:9][N+:10]3[N:11]([CH2:18][CH2:19][CH2:20][O:21]C=O)[C:12]([NH:15]C=O)=[CH:13][CH:14]=3)[CH2:7][S:8][C@H:3]12.CO.[ClH:31]>C(OCC)(=O)C>[ClH:31].[ClH:31].[ClH:31].[NH2:1][C@@H:2]1[C:27](=[O:28])[N:4]2[C:5]([C:24]([O-:26])=[O:25])=[C:6]([CH2:9][N+:10]3[N:11]([CH2:18][CH2:19][CH2:20][OH:21])[C:12]([NH2:15])=[CH:13][CH:14]=3)[CH2:7][S:8][C@H:3]12

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 131717750HCID 131717750, compound

Product 1

HCID 131717749HCID 131717749, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Bis(trifluoroacetic acid salts) of 7β-amino-3-[3-formamido-2-(3-formyloxypropyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate (5.30 g) was added to methanol (31.8 ml). Concentrated hydrochloric acid was added dropwise thereto with stirring at room temperature. The mixture was stirred for 3 hours. The reaction mixture was pulverized with ethyl acetate (400 ml) to give 7β-amino-3-[3-amino-2-(3-hydroxypropyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate trihydrochloride.

Workup

  1. stirringThe mixture was stirred for 3 hours

Sources & evidence

ORD record
ord-e9a973dff9854f2c9ec654b1ff95d37e
Source dataset
uspto-grants-1993_02
Patent number
US05187160

Reaction notes

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