Hydrochloric Acid → HCID 131717754, compound

HRID 2082028Notes

Reaction equation

HRID 2082028 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:33][O:34][CH2:35][CH3:36])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([O-:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:20]([CH2:25][CH2:26][OH:27])[C:21]([NH2:24])=[CH:22][CH:23]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[ClH:37]>O>[ClH:37].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:33][O:34][CH2:35][CH3:36])[C:8]([NH:10][C@@H:11]2[C:31](=[O:32])[N:13]3[C:14]([C:28]([O-:30])=[O:29])=[C:15]([CH2:18][N+:19]4[N:20]([CH2:25][CH2:26][OH:27])[C:21]([NH2:24])=[CH:22][CH:23]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131717752HCID 131717752, compound

Product 1

HCID 131717754HCID 131717754, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 7β-[2-(2-aminothiazol-4-yl)-2-ethoxyiminoacetamido ]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio ]methyl-3-cephem-4-carboxylate (syn isomer) (300 mg) in water (15 ml) was added 1N hydrochloric acid (0.56 ml). The mixture was lyophilized to give 7β-[2-(2-aminothiazol-4-yl)-2-ethoxyiminoacetamido ]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio ]methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (310 mg).

Sources & evidence

ORD record
ord-910abe3e8d9a430cbd9bb6fe41fefd84
Source dataset
uspto-grants-1993_02
Patent number
US05187160

Reaction notes

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