2-Bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylic acid → tert-butyl 2-bromo-4-(1-(2,2-difluoroethyl)-5-(4-hydroxyazepan-1-yl)-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate

HRID 208203Notes

Reaction equation

HRID 208203 reaction equation
[Br:19][c:20]1[s:21][c:22]([NH:28][C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[c:23]([C:25](=[O:26])[OH:27])[n:24]1.[NH2:1][c:2]1[cH:3][n:4][n:5]([CH2:15][CH:16]([F:17])[F:18])[c:6]1[N:7]1[CH2:8][CH2:9][CH:10]([OH:14])[CH2:11][CH2:12][CH2:13]1>>[NH:1]([c:2]1[cH:3][n:4][n:5]([CH2:15][CH:16]([F:17])[F:18])[c:6]1[N:7]1[CH2:8][CH2:9][CH:10]([OH:14])[CH2:11][CH2:12][CH2:13]1)[C:25]([c:23]1[c:22]([NH:28][C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[s:21][c:20]([Br:19])[n:24]1)=[O:26]

Participants

3

Reactant 2

HCID 581821562-Bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylic acidHCID 866799701-(4-amino-1-(2,2-difluoroethyl)-1H-pyrazol-5-yl)azepan-4-ol

Product 1

HCID 86679969tert-butyl 2-bromo-4-(1-(2,2-difluoroethyl)-5-(4-hydroxyazepan-1-yl)-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate

Sources & evidence

ORD record
ord-6fea4bc3565a4367873516e964e1f1fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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