Phenacyl bromide → HCID 178441935, compound

HRID 2082056Notes

Reaction equation

HRID 2082056 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:10][CH:9]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N:3]=1.[CH2:26]([Br:35])[C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:28]>>[Br-:35].[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:12][CH:13]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N+:3]=1[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:28]

Participants

3

Reactant 2

HCID 6259Phenacyl bromideHCID 100652943-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole

Product 1

HCID 178441935HCID 178441935, compoundYield 86%

Procedure

Reaction of 3-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole (from Example 1, Step D) with phenacyl bromide (2-bromoacetophenone) according to the procedure of Example 1, Step E, gave an 86% yield of the title compound as a stiff, yellow foam, suitable for use without further purification.

Sources & evidence

ORD record
ord-fa5e9053dc33426293aac82b760793ed
Source dataset
uspto-grants-1993_02
Patent number
US05187179

Reaction notes

Loading…