1-Bromo-2-butanone → HCID 178441937, compound

HRID 2082060Notes

Reaction equation

HRID 2082060 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:10][CH:9]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N:3]=1.[Br:26][CH2:27][C:28](=[O:31])[CH2:29][CH3:30]>>[Br-:26].[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:12][CH:13]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N+:3]=1[CH2:27][C:28](=[O:31])[CH2:29][CH3:30]

Participants

3

Reactant 2

HCID 131561-Bromo-2-butanoneHCID 100652943-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole

Product 1

HCID 178441937HCID 178441937, compound

Procedure

Reaction of 3-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole (from Example 1, Step D) with 1-bromo-2-butanone according to the procedure of Example 1, Step E, gave a quantitative yield of the title compound as a white solid, mp 221°-224° C.

Sources & evidence

ORD record
ord-2934c7b660af4d06aa5e3c4c85799c2e
Source dataset
uspto-grants-1993_02
Patent number
US05187179

Reaction notes

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