2-Propanone, 1-bromo-1-phenyl- → HCID 178441924, compound

HRID 2082064Notes

Reaction equation

HRID 2082064 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:10][CH:9]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N:3]=1.[Br:26][CH:27]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:28]([CH3:30])=[O:29]>>[Br-:26].[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:12][CH:13]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N+:3]=1[CH:27]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:28](=[O:29])[CH3:30]

Participants

3

Reactant 2

HCID 908702-Propanone, 1-bromo-1-phenyl-HCID 100652943-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole

Product 1

HCID 178441924HCID 178441924, compound

Procedure

Reaction of 3-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole (from Example 1, Step D) with 1-bromo-1-phenylacetone [A. C. B. Smith and W. Wilson, J. Chem. Soc., 1342 (1955)] according to the procedure of Example 1, Step E, gave an essentially quantitiative yield of the title compound as a yellow oil, suitable for use in the next step.

Sources & evidence

ORD record
ord-198f837d02c84c8a9d8c82d7ceea0f0e
Source dataset
uspto-grants-1993_02
Patent number
US05187179

Reaction notes

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