反应详情

温度

0 °C

To a suspension of potassium tert-butoxide (2.61 g, 23.3 mmol) in ether (100 mL) was added methyltriphenylphosphonium bromide (8.34 g, 23.3 mmol) and the solution was brought to reflux for 15 min. It was then cooled to 0° C. and 3-(4-fluorophenoxy)benzaldehyde (4.80 g, 22.2 mmol) was added. The reaction was stirred for 5 min at 0° C., the cooling bath was withdrawn and the reaction allowed to warm to ambient temperature and stir for 45 min. It was then filtered through Celite and concentrated. The resulting residue was chromatographed (silica gel; hexanes, ether 96:4) to afford 4.09 g (86%) of 3-(4-fluorophenoxy)styrene as a colorless oil.

1. temperatureto reflux for 15 min
2. customthe cooling bath was withdrawn
3. temperatureto warm to ambient temperature
4. stirringstir for 45 min
5. filtrationIt was then filtered through Celite
6. concentrationconcentrated
7. customThe resulting residue was chromatographed (silica gel; hexanes, ether 96:4)