反应详情

A solution of 3-(3-(4-fluorophenoxy)phenyl)cyclobutanone (2.59 g, 10.1 mmol) and hydroxylamine hydrochloride (844 mg, 12.1 mmol) in 1:1 ethanol:pyridine (50 mL) was stirred for 36 hours. It was then concentrated in vacuo. The residue was taken up in brine (50 mL) and extracted with ethyl acetate (3×50 mL). The organics were combined, dried over MgSO4 and concentrated to afford 3-(3-(4-fluorophenoxy)phenyl)cyclobutanone oxime which was used as is.

1. concentrationIt was then concentrated in vacuo
2. extractionextracted with ethyl acetate (3×50 mL)
3. dry with materialdried over MgSO4
4. concentrationconcentrated