N-(2,3-Epoxypropyl)phthalimide → HCID 13365967, compound

HRID 2082136Notes

Reaction equation

HRID 2082136 reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=[O:14].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1>C(O)(C)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][N:32]([CH2:15][CH:2]([OH:1])[CH2:3][N:4]4[C:12](=[O:13])[C:11]5[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=5)[C:5]4=[O:14])[CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 4061276HCID 4061276, compound

Product 1

HCID 13365967HCID 13365967, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.022 mol of 2-(2,3-epoxypropyl)isoindole-1,3(2H)dione, 0.02 mol of 1-(5-(4-chlorophenyl)-2-pyrimidinyl)piperazine and 70 ml of isopropanol are heated to boiling for 2 hours. The mixture is evaporated and the residue is purified by column chromatography on silica gel 60. After elution with methylene chloride/alcohol (96:4), the compound is stirred with alcohol and filtered off with suction.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is purified by column chromatography on silica gel 60
  3. washAfter elution with methylene chloride/alcohol (96:4)
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-6c83661851ae4c329f6484befd612b93
Source dataset
uspto-grants-1993_02
Patent number
US05187276

Reaction notes

Loading…