Potassium Hydroxide → HCID 12674277, compound

HRID 2082141Notes

Reaction equation

HRID 2082141 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([N:13]3[CH2:18][CH2:17][N:16](C(OCC)=O)[CH2:15][CH2:14]3)=[N:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>C(O)C.O>[C:1]1([C:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 3631156HCID 3631156, compound

Product 1

HCID 12674277HCID 12674277, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

0.04 mol of ethyl 1-(5-phenyl-2-pyrimidinyl)-4-piperazinecarboxylate are boiled under reflux with 0.78 mol of KOH in 400 ml of C2H5OH and 40 ml of H2O under N2 protective gas for 15 hours. The mixture is evaporated to dryness, water is added and the residue is taken up in CH2Cl2. After washing with water, the organic phase is separated off and evaporated to dryness, whereupon the amine is obtained as crystals.

Workup

  1. customThe mixture is evaporated to dryness, water
  2. additionis added
  3. washAfter washing with water
  4. customthe organic phase is separated off
  5. customevaporated to dryness, whereupon the amine
  6. customis obtained as crystals

Sources & evidence

ORD record
ord-395522a75b634041b750ac3d7d6c648a
Source dataset
uspto-grants-1993_02
Patent number
US05187276

Reaction notes

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