Ammonia → HCID 131717780, compound

HRID 2082236Notes

Reaction equation

HRID 2082236 reaction equation
[NH:1]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C@@H:2]([C:13]([NH:15][C@H:16]([C:24](OCC1C=CC=CC=1)=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[NH3:41]>>[NH:1]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C@@H:2]([C:13]([NH:15][C@H:16]([C:24]([NH2:41])=[O:25])[CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 15630270HCID 15630270, compound

Product 1

HCID 131717780HCID 131717780, compound

Procedure

A mixture of Boc-D-Trp-Phe-OBzl (1.0 g) and 24% methanolic ammonia (20 ml) was allowed to stand at room temperature in a sealed tube for 18 hours. After evaporation, the residual crystals were collected and recrystallized from a mixture of water and ethanol to give Boc-D-Trp-Phe-NH2 (0.63 g).

Workup

  1. customAfter evaporation
  2. customthe residual crystals were collected
  3. customrecrystallized from a mixture of water and ethanol

Sources & evidence

ORD record
ord-86577429f33441a29ea1b3acd16569dd
Source dataset
uspto-grants-1993_02
Patent number
US05187156

Reaction notes

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