Sodium Methoxide → HCID 67783632, compound

HRID 2082261Notes

Reaction equation

HRID 2082261 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7](F)[N:6]1[O:13][CH:14]([F:16])[F:15]>CO>[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7]([O:2][CH3:1])[N:6]1[O:13][CH:14]([F:16])[F:15]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 67783290HCID 67783290, compound

Product 1

HCID 67783632HCID 67783632, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8.4 g (0.047 mol) of 30% strength sodium methylate were added to a mixture of 10 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine in 100 ml of methanol at 0° C. in the course of 15 minutes, while stirring. Stirring was carried out for one hour at 0° C., after which the mixture was evaporated down under reduced pressure, the residue was taken up in methylene chloride and the solution was extracted with water. Drying and evaporation gave 10.4 g (98.5% of theory) of the title compound of melting point 109°-111° C.

Workup

  1. stirringStirring
  2. customafter which the mixture was evaporated down under reduced pressure
  3. extractionthe solution was extracted with water
  4. customDrying
  5. customevaporation

Sources & evidence

ORD record
ord-c795c99e5e344231b09cc9f4a1defcda
Source dataset
uspto-grants-1993_02
Patent number
US05188657

Reaction notes

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