Methylamine → 2-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

Participants

Reaction Steps

3.5 g (0.111 mol) of gaseous methylamine were passed into a solution of 11 g (0.055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 150 ml of tetrahydrofuran at 0° C. in the course of 20 minutes, while stirring. Stirring was continued for one hour at 0° C. and overnight at 22° C. The reaction mixture was evaporated down under reduced pressure and the residue was stirred with water and dried. 10.8 g (93.1% of theory) of the title compound of melting point 155°-157° C. (decomposition) were obtained.

Provenance & Evidence