Methylamine → 2-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

HRID 2082264Notes

Reaction equation

HRID 2082264 reaction equation
[CH3:1][NH2:2].[NH2:3][C:4]1[N:9]=[C:8](F)[N:7]=[C:6]([O:11][C:12]([F:15])([F:14])[F:13])[N:5]=1>O1CCCC1>[NH2:3][C:4]1[N:9]=[C:8]([NH:2][CH3:1])[N:7]=[C:6]([O:11][C:12]([F:15])([F:14])[F:13])[N:5]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103972-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.5 g (0.111 mol) of gaseous methylamine were passed into a solution of 11 g (0.055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 150 ml of tetrahydrofuran at 0° C. in the course of 20 minutes, while stirring. Stirring was continued for one hour at 0° C. and overnight at 22° C. The reaction mixture was evaporated down under reduced pressure and the residue was stirred with water and dried. 10.8 g (93.1% of theory) of the title compound of melting point 155°-157° C. (decomposition) were obtained.

Workup

  1. stirringStirring
  2. customThe reaction mixture was evaporated down under reduced pressure
  3. stirringthe residue was stirred with water
  4. customdried

Sources & evidence

ORD record
ord-a6210186f99e4d27bfcf0cb41ada8851
Source dataset
uspto-grants-1993_02
Patent number
US05188657

Reaction notes

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