2,6-Dichloropyridine → HCID 19778080, compound

Participants

Reaction Steps

A mixture of 1.1 g (4 mmol) of 1,3-dimethyl-4-(2-chlorophenylthio)-5-hydroxypyrazole and 5.0 g (34 mmol) of 2,6-dichloropyridine was refluxed with heating for 20 hours. After completing the reaction, the reaction mixture was purified by means of silica gel column chromatography (developing solution: ethyl acetate-hexane (2:1 v/v)) to give 0.40 g of 1,3-dimethyl-4-(2-chlorophenylthio)-5-(6-chloropyridine-2-yloxy)pyrazole.

Provenance & Evidence