2,6-Dichloropyridine → HCID 19778080, compound

HRID 2082298Notes

Reaction equation

HRID 2082298 reaction equation
[CH3:1][N:2]1[C:6]([OH:7])=[C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:4]([CH3:16])=[N:3]1.[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20](Cl)[N:19]=1>>[CH3:1][N:2]1[C:6]([O:7][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[N:19]=2)=[C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:4]([CH3:16])=[N:3]1

Participants

3

Reactant 2

HCID 169892,6-DichloropyridineHCID 178434080HCID 178434080, compound

Product 1

HCID 19778080HCID 19778080, compoundYield 27.3%

Procedure

A mixture of 1.1 g (4 mmol) of 1,3-dimethyl-4-(2-chlorophenylthio)-5-hydroxypyrazole and 5.0 g (34 mmol) of 2,6-dichloropyridine was refluxed with heating for 20 hours. After completing the reaction, the reaction mixture was purified by means of silica gel column chromatography (developing solution: ethyl acetate-hexane (2:1 v/v)) to give 0.40 g of 1,3-dimethyl-4-(2-chlorophenylthio)-5-(6-chloropyridine-2-yloxy)pyrazole.

Workup

  1. temperaturewas refluxed
  2. temperaturewith heating for 20 hours
  3. customthe reaction
  4. customthe reaction mixture was purified by means of silica gel column chromatography (developing solution: ethyl acetate-hexane (2:1 v/v))

Sources & evidence

ORD record
ord-d3dad90c0f204bad8c9e66ac4d663c56
Source dataset
uspto-grants-1993_02
Patent number
US05189040

Reaction notes

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