Hydrochloric Acid → HCID 19778043, compound

Participants

Reaction Steps

[1-(4-(1H-Imidazol-1-yl)benzoyl]-4-piperidinyl]carbamic acid, 1,1-dimethylethyl ester (131.6 g, 355 mmol) is dissolved in methanol (800 mL) at 0° C., and the solution is saturated with HCl gas. The mixture is stirred for 3 hr at room temperature, after which ether is added to give a turbid solution. The resulting precipitate is collected and air dried to afford the title compound.

Provenance & Evidence