Hydrochloric Acid → HCID 19778043, compound

HRID 2082312Notes

Reaction equation

HRID 2082312 reaction equation
[N:1]1([C:6]2[CH:27]=[CH:26][C:9]([C:10]([N:12]3[CH2:17][CH2:16][CH:15]([NH:18]C(=O)OC(C)(C)C)[CH2:14][CH2:13]3)=[O:11])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:28].CCOCC>CO>[ClH:28].[ClH:28].[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:10]([N:12]3[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14][CH2:13]3)=[O:11])=[CH:26][CH:27]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 57033164HCID 57033164, compound

Product 1

HCID 19778043HCID 19778043, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

[1-(4-(1H-Imidazol-1-yl)benzoyl]-4-piperidinyl]carbamic acid, 1,1-dimethylethyl ester (131.6 g, 355 mmol) is dissolved in methanol (800 mL) at 0° C., and the solution is saturated with HCl gas. The mixture is stirred for 3 hr at room temperature, after which ether is added to give a turbid solution. The resulting precipitate is collected and air dried to afford the title compound.

Workup

  1. customto give a turbid solution
  2. customThe resulting precipitate is collected
  3. customair dried

Sources & evidence

ORD record
ord-d741e4bdcb484ef1b3ea8d75d8ccfa74
Source dataset
uspto-grants-1993_02
Patent number
US05189036

Reaction notes

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