N-(1-benzylpiperid-4-yl)-N-methylpropionamide → N-Methyl-N-(piperidin-4-yl)propionamide

HRID 2082345Notes

Reaction equation

HRID 2082345 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 19761195N-(1-benzylpiperid-4-yl)-N-methylpropionamide

Product 1

HCID 19761222N-Methyl-N-(piperidin-4-yl)propionamideYield 60%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

31 g of the amine obtained in Stage B are hydrogenated in 350 ml of ethanol with 1 g of palladium hydroxide at atmospheric pressure and room temperature. The mixture is filtered and evaporated to yield the desired product in the form of an oil.

Workup

  1. filtrationThe mixture is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-0295d3c8d845438e84752f73a7d8dbc2
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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