Dimethylacetamide → HCID 19761210, compound

HRID 2082359Notes

Reaction equation

HRID 2082359 reaction equation
[C:1]([CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]2[O:14][CH2:15][O:16][C:9]=12)C(O)=O)#[N:2].CN(C)C(=O)C>O>[C:1]([CH2:3][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]2[O:14][CH2:15][O:16][C:9]=12)#[N:2]

Participants

4

Reactant 2

HCID 31374DimethylacetamideHCID 19761227HCID 19761227, compound

Product 1

HCID 19761210HCID 19761210, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

60.6 g of acid prepared in Stage B are mixed with 115 ml of N,N-dimethylacetamide and the mixture is heated at 150° C. for approximately 2 hours and then allowed to cool, taken up in water and extracted with diethyl ether. The ethereal phases are washed with a sodium hydrogen carbonate solution and then with water and dried to yield the desired compound in the form of an oil.

Workup

  1. temperatureto cool
  2. extractionextracted with diethyl ether
  3. washThe ethereal phases are washed with a sodium hydrogen carbonate solution
  4. dry with materialwith water and dried

Sources & evidence

ORD record
ord-16675256c8f24fa3b24ab47590ed501b
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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