Bromine → HCID 19761191, compound

HRID 2082360Notes

Reaction equation

HRID 2082360 reaction equation
[Br:1]Br.[C:3]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]2[O:13][CH2:14][O:15][C:8]=12)#[N:4].C([O-])(=O)C.[K+]>C(O)(=O)C.O>[Br:1][C:12]1[C:7]([CH2:6][CH2:5][C:3]#[N:4])=[C:8]2[O:15][CH2:14][O:13][C:9]2=[CH:10][CH:11]=1

Participants

6

Reactant 3

HCID 24408BromineHCID 517044Potassium AcetateHCID 19761210HCID 19761210, compound

Product 1

HCID 19761191HCID 19761191, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent2×HCID 962WaterSolvent

Procedure

16.4 ml of bromine dissolved in 35 ml of acetic acid are poured at 18° C. onto 53.6 g of nitrile obtained in Stage C dissolved in 179 ml of acetic acid. The mixture is stirred for 1 hour, then left overnight at room temperature and hydrolysed with 31.5 g of potassium acetate dissolved in 150 ml of water and 196.5 g of ice. The mixture is extracted with diethyl ether and the ethereal phase is washed several times with water and dried.

Workup

  1. extractionThe mixture is extracted with diethyl ether
  2. washthe ethereal phase is washed several times with water
  3. customdried

Sources & evidence

ORD record
ord-32564933cdb844db860fcc6643e3496f
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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