Glyoxylic Acid → HCID 18951343, compound

HRID 2082479Notes

Reaction equation

HRID 2082479 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[C:10]([OH:14])(=[O:13])[CH:11]=O>CO>[NH2:4][C:3]1[C:5]([CH3:9])=[CH:6][C:7]([CH:11]([C:7]2[CH:6]=[C:5]([CH3:9])[C:3]([NH2:4])=[C:2]([CH3:1])[CH:8]=2)[C:10]([OH:14])=[O:13])=[CH:8][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 760Glyoxylic AcidHCID 68962,6-Dimethylaniline

Product 1

HCID 18951343HCID 18951343, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2,6-dimethylaniline (40 parts) and methanol (150 parts) was stirred at ambient temperature. Glyoxylic acid 50% w/v (24.5 parts) was added and the mixture was stirred for 24 hours at ambient temperature. The precipitated product was isolated by filtration, washed with methanol (30 parts) and dried to yield di(4-amino-3,5-dimethylphenyl)acetic acid (44.3 parts).

Workup

  1. additionwas added
  2. stirringthe mixture was stirred for 24 hours at ambient temperature
  3. customThe precipitated product was isolated by filtration
  4. washwashed with methanol (30 parts)
  5. customdried

Sources & evidence

ORD record
ord-2a7b205108374f2a86d4b3b4fb2e5e7f
Source dataset
uspto-grants-1993_02
Patent number
US05189181

Reaction notes

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