HRID2082613

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)C1=C(CI)CS[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N12

HCID14488848

未命名化合物

HCID21226206

未命名化合物

结构：CC(=O)Oc1ccc(C(=O)[O-])cc1OC(C)=O.[Na+]

HCID23716498

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Oc1ccc(C(=O)OCC2=C(C(=O)OC(C)(C)C)N3C(=O)C(NC(=O)COc4ccccc4)C3SC2)cc1OC(C)=O

HCID76083593

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

By following the procedures and conditions described in Example 4, 2.33 g (8.95 mmol) of sodium 3,4-diacetoxybenzoate in 100 mL of DMF added to 4.75 g (8.95 mmol) of (6R-trans)-3-(iodomethyl)-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1,1-dimethylethyl ester in 50 mL of DMF, followed by stirring for 2 hours, gave 3.36 g (58.5%) of a cream colored solid after silica gel chromatography (6:4 hexane/EtOAc).

WORKUP

后处理

customgave 3.36 g (58.5%) of a cream

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-352f0048a98e448ea95cedf016e241c2
来源数据集: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05189157
来源说明: uspto-grants-1993_02

反应 SMILES

[C:1]([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][C:15](=[O:17])[CH3:16])[C:8]([O-:10])=[O:9])(=[O:3])[CH3:2].[Na+].[CH3:19][C:20]([O:23][C:24]([C:26]1[N:27]2[C@H:30]([S:31][CH2:32][C:33]=1[CH2:34]I)[C@H:29]([NH:36][C:37](=[O:46])[CH2:38][O:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:28]2=[O:47])=[O:25])([CH3:22])[CH3:21].CCCCCC.CCOC(C)=O>CN(C=O)C>[CH3:22][C:20]([O:23][C:24]([C:26]1[N:27]2[CH:30]([S:31][CH2:32][C:33]=1[CH2:34][O:9][C:8](=[O:10])[C:7]1[CH:11]=[CH:12][C:13]([O:14][C:15](=[O:17])[CH3:16])=[C:5]([O:4][C:1](=[O:3])[CH3:2])[CH:6]=1)[CH:29]([NH:36][C:37](=[O:46])[CH2:38][O:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)[C:28]2=[O:47])=[O:25])([CH3:19])[CH3:21]