Triphenylphosphine → HCID 77376260, compound

HRID 2082619Notes

Reaction equation

HRID 2082619 reaction equation
[CH2:1]([CH:3]1[CH:29]=[C:28]([CH3:30])[CH:27]([F:31])[CH:26]([CH3:32])[CH2:25][CH:24]([O:33][CH3:34])[CH:23]2[O:35][C:19]([OH:39])([CH:20]([CH3:38])[CH2:21][CH:22]2[O:36][CH3:37])[C:18](=[O:40])[C:17](=[O:41])[N:16]2[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[C:10](=[O:42])[O:9][CH:8]([C:43]([CH3:56])=[CH:44][CH:45]2[CH2:50][CH2:49][CH:48]([N:51]=[N+]=[N-])[CH:47]([O:54][CH3:55])[CH2:46]2)[CH:7]([CH3:57])[CH:6]([OH:58])[CH2:5][C:4]1=[O:59])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([CH:3]1[CH:29]=[C:28]([CH3:30])[CH:27]([F:31])[CH:26]([CH3:32])[CH2:25][CH:24]([O:33][CH3:34])[CH:23]2[O:35][C:19]([OH:39])([CH:20]([CH3:38])[CH2:21][CH:22]2[O:36][CH3:37])[C:18](=[O:40])[C:17](=[O:41])[N:16]2[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15]2)[C:10](=[O:42])[O:9][CH:8]([C:43]([CH3:56])=[CH:44][CH:45]2[CH2:50][CH2:49][CH:48]([NH2:51])[CH:47]([O:54][CH3:55])[CH2:46]2)[CH:7]([CH3:57])[CH:6]([OH:58])[CH2:5][C:4]1=[O:59])[CH3:2]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 86746578HCID 86746578, compound

Product 1

HCID 77376260HCID 77376260, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 17-ethyl-20-fluoro-1, 14-dihydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (28 l mg) and triphenylphosphine (9 mg) in 1 ml of wet toluene is stirred at 70° C. overnight. The solvent is removed under reduced pressure, and the residue was purified by preparative tlc on silica gel to give the title compound.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customthe residue was purified by preparative tlc on silica gel

Sources & evidence

ORD record
ord-0cf06fd0ce994a9c97292aad878659bd
Source dataset
uspto-grants-1993_02
Patent number
US05189042

Reaction notes

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