Ethylamine → HCID 20359979, compound

HRID 2082637Notes

Reaction equation

HRID 2082637 reaction equation
[CH:1]1([NH:4][C:5]2[CH:10]=[C:9]([Cl:11])[N:8]=[C:7](Cl)[N:6]=2)[CH2:3][CH2:2]1.[CH2:13]([NH2:15])[CH3:14]>C(O)C>[CH2:13]([NH:15][C:7]1[N:6]=[C:5]([NH:4][CH:1]2[CH2:3][CH2:2]2)[CH:10]=[C:9]([Cl:11])[N:8]=1)[CH3:14]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 203599822,6-Dichloro-N-cyclopropylpyrimidin-4-amine

Product 1

HCID 20359979HCID 20359979, compoundYield 74.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 130.5 g (0.64 mol) of 4-cyclopropylamino-2,6-dichloropyrimidine, 576 g (6.4 mols) of ethylamine and 500 ml of ethanol is heated to the reflux temperature for 3 hours. The isomer 6-ethylamino-4-cyclopropylamino-2-chloropyrimidine which crystallises out on cooling is removed by filtration. The filtrate is concentrated to dryness on a rotary evaporator and the residue is recrystallised from methanol. 102 g of colourless crystals of melting point 86°-88° are thus obtained.

Workup

  1. temperatureis heated to the reflux temperature for 3 hours
  2. customThe isomer 6-ethylamino-4-cyclopropylamino-2-chloropyrimidine which crystallises out
  3. temperatureon cooling
  4. customis removed by filtration
  5. concentrationThe filtrate is concentrated to dryness on a rotary evaporator
  6. customthe residue is recrystallised from methanol

Sources & evidence

ORD record
ord-4f883730ee0e4231aeee343066c1726d
Source dataset
uspto-grants-1978_04
Patent number
US04082535

Reaction notes

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