HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → HCID 20359979, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 2,6-Dichloro-N-cyclopropylpyrimidin-4-amine | HCID 20359982 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20359979 | HCID 20359979 | 74.9% |
Reaction Steps
A mixture of 130.5 g (0.64 mol) of 4-cyclopropylamino-2,6-dichloropyrimidine, 576 g (6.4 mols) of ethylamine and 500 ml of ethanol is heated to the reflux temperature for 3 hours. The isomer 6-ethylamino-4-cyclopropylamino-2-chloropyrimidine which crystallises out on cooling is removed by filtration. The filtrate is concentrated to dryness on a rotary evaporator and the residue is recrystallised from methanol. 102 g of colourless crystals of melting point 86°-88° are thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082535 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-4f883730ee0e4231aeee343066c1726d |
| Source note | uspto-grants-1978_04 |