Triethylamine → HCID 20359940, compound

HRID 2082650Notes

Reaction equation

HRID 2082650 reaction equation
[Cl:1][C:2]1[C:3]([Br:17])=[C:4]2[N:11]([OH:12])[C:10]([C:13]([F:16])([F:15])[F:14])=[N:9][C:5]2=[N:6][C:7]=1[Br:8].[CH3:18][N:19]=[C:20]=[O:21].C(N(CC)CC)C>C(OCC)C>[CH3:18][NH:19][C:20]([O:12][N:11]1[C:4]2[C:5](=[N:6][C:7]([Br:8])=[C:2]([Cl:1])[C:3]=2[Br:17])[N:9]=[C:10]1[C:13]([F:14])([F:16])[F:15])=[O:21]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 20355443HCID 20355443, compound

Product 1

HCID 20359940HCID 20359940, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

6-Chloro-5,7-dibromo-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine (0.9 gram) was mixed with ether (15 milliliters) and methyl isocyanate (2 milliliters) and stirred for fifteen minutes. Triethylamine (0.01 milliliter) was added, and the solution became homogenous. It was permitted to stand for sixteen hours, diluted with 50 milliliters diethyl ether; washed with 0.5N HCl, water, and saturated NaCl; then dried over magnesium sulfate, and evaporated. The resulting 1-(methylcarbamoyloxy)-6 -chloro-5,7 -dibromo-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine product was recrystallized from chloroform, m.p., 216° C.

Workup

  1. waitto stand for sixteen hours
  2. washwashed with 0.5N HCl, water, and saturated NaCl
  3. dry with materialthen dried over magnesium sulfate
  4. customevaporated
  5. customThe resulting 1-(methylcarbamoyloxy)-6 -chloro-5,7 -dibromo-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine product was recrystallized from chloroform
  6. customm.p., 216° C.

Sources & evidence

ORD record
ord-47b98b43b97a4f5a9f78170d2620e614
Source dataset
uspto-grants-1978_04
Patent number
US04082534

Reaction notes

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