Hydrochloric Acid → HCID 178505637, compound

HRID 2082683Notes

Reaction equation

HRID 2082683 reaction equation
[OH-].[K+].[CH:3]([NH:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])=[S:8])=O.Cl>O>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:9]1[CH:3]=[N:5][N:6]=[C:7]1[SH:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

Product 1

HCID 178505637HCID 178505637, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

One and one-tenth grams (20 mmoles) of potassium hydroxide were dissolved in 50 ml. of water. 1-Formyl-4-(2-fluorophenyl)thiosemicarbazide, 3.5 g. (16.5 mmoles), was dissolved in the basic solution by warming on the steam bath until solution was completed. The heating was continued for one hour. The cooled reaction mixture was poured into a dilute solution of hydrochloric acid. The insoluble product was recovered from the acidic solution by filtration. The product was washed with water, collected and dried. The yield was 2.5 g. of 4-(2-fluorophenyl)-1,2,4-triazole-3-thiol, m.p. about 166°-167° C.

Workup

  1. dissolution(16.5 mmoles), was dissolved in the basic solution
  2. temperatureby warming on the steam bath until solution
  3. customThe cooled reaction mixture
  4. filtrationThe insoluble product was recovered from the acidic solution by filtration
  5. washThe product was washed with water
  6. customcollected
  7. customdried

Sources & evidence

ORD record
ord-bf4f3ac0f66845d5aa3676ec412fcb9a
Source dataset
uspto-grants-1978_04
Patent number
US04082762

Reaction notes

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