反应详情

One and one-tenth grams (20 mmoles) of potassium hydroxide were dissolved in 50 ml. of water. 1-Formyl-4-(2-fluorophenyl)thiosemicarbazide, 3.5 g. (16.5 mmoles), was dissolved in the basic solution by warming on the steam bath until solution was completed. The heating was continued for one hour. The cooled reaction mixture was poured into a dilute solution of hydrochloric acid. The insoluble product was recovered from the acidic solution by filtration. The product was washed with water, collected and dried. The yield was 2.5 g. of 4-(2-fluorophenyl)-1,2,4-triazole-3-thiol, m.p. about 166°-167° C.

1. dissolution(16.5 mmoles), was dissolved in the basic solution
2. temperatureby warming on the steam bath until solution
3. customThe cooled reaction mixture
4. filtrationThe insoluble product was recovered from the acidic solution by filtration
5. washThe product was washed with water
6. customcollected
7. customdried