反应详情

To a solution of 2.7 parts of 5-chloro-2-formamidobenzophenone in 40 volume parts of ethanol is added 2.5 volume parts of hydrazine hydrate, followed by refluxing for 20 minutes. After cooling, the resulting crystals are recovered by filtration and washed with ethanol and ether and then dried. This procedure gives 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-phenylquinazoline as crystals melting at 189° to 192° C. Yield: 95%.

1. temperatureby refluxing for 20 minutes
2. temperatureAfter cooling
3. filtrationthe resulting crystals are recovered by filtration
4. washwashed with ethanol and ether
5. customdried