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Acetic Acid → Ethyl 1,6-dihydro-6-oxo-2-(2-propoxyphenyl)pyrimidine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | n-Propoxybenzamidine methyl sulfate | HCID 86734867 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 1,6-dihydro-6-oxo-2-(2-propoxyphenyl)pyrimidine-5-carboxylate | HCID 12535801 | 89% |
反応手順
A mixture of 2;l -n-propoxybenzamidine methyl sulfate (7.4 g., 0.0255 mole), potassium carbonate (3.53 g., 0.025 mole), and diethyl ethoxymethylenemalonate (5.99 g., 0.0277 mole) in ethanol (80 ml.) was heated under reflux with stirring for 17 hours. The cooled mixture was added to ice-water (160 ml.) which was then acidified with glacial acetic acid. The precipitate was collected by filtration, washed with water, and dried to give the title compound (6.55 g., 89%), m.p. 106°-107°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04082751 |
| 出典データセット | uspto-grants-1978_04 |
| ORD ID | ord-d52d8857df584e0b95928f02124bd8e0 |
| 出典メモ | uspto-grants-1978_04 |