反应详情

A mixture of 2;l -n-propoxybenzamidine methyl sulfate (7.4 g., 0.0255 mole), potassium carbonate (3.53 g., 0.025 mole), and diethyl ethoxymethylenemalonate (5.99 g., 0.0277 mole) in ethanol (80 ml.) was heated under reflux with stirring for 17 hours. The cooled mixture was added to ice-water (160 ml.) which was then acidified with glacial acetic acid. The precipitate was collected by filtration, washed with water, and dried to give the title compound (6.55 g., 89%), m.p. 106°-107°.

1. temperaturewas heated
2. temperatureunder reflux
3. filtrationThe precipitate was collected by filtration
4. washwashed with water
5. customdried